Pubertal changes in biochemical markers of growth.

摘要: Puberty is a crucial period of life during which dramatic hormonal changes induce notable modifications in linear growth, bone mass and body composition. These are associated with variations some biochemical parameters such as markers turnover leptin, may reflect growth fat mass, respectively. Children hormone (GH) deficiency have reduced concentrations markers, increase GH administration, while the levels leptin decrease. There been few studies analysing behaviour puberty GH-treated GH-deficient patients no leptin. Results from longitudinal study showed that there was change serum osteocalcin, carboxy-terminal propeptide type I procollagen, cross-linked telopeptide collagen children. Some shown after short-term treatment predict response (at 6-12 months) to administration At present, insufficient data available for clinical use these pubertal development predictors long-term children deficiency. Nevertheless, more possibly new might improve accuracy prediction models future.