Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen.

摘要: To better define the effect of systemic glucocorticoids on cutaneous early and late phase response (LPR), nine atopic subjects were examined in a double-blind cross-over study using skin chambers fixed over denuded blisters. A challenge was carried out by placing allergen chamber for 60 min who received either 3-day pretreatment with mg/day prednisone or placebo. Skin cell counts inflammatory mediators (histamine, PGD2, leukotriene C4 (LTC4)) measured at hourly intervals 12 h. Prednisone did not alter immediate erythema release histamine but ablated secondary rise histamine. The median values during h 10, 11, placebo visits 3.73 0.22 ng/ml, respectively (p less than equal to 0.02). PGD2 production; however, LTC4 production suppressed LPR. cumulative 7, 8, 9 5.6-fold 0.05) more after pretreatment. altered cellular traffic dramatically it mediators. influx eosinophils, which peaked 9th 10th placebo-treated patients, completely blocked 0.02) every from 6 through 12. basophils, started 12th all time points prednisone-treated patients. There no significant alteration neutrophil transit into induced prednisone. We suggest that selective blockade eosinophil basophil associated decrease may contribute clinical expression