The role of matrilysin (MMP-7) in leukaemia cell invasion.
作者： Conor C. Lynch , Susan Mc Donnell
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摘要: The matrix metalloproteinases (MMPs) are important in tumour cell invasion and metastasis many common cancers. However, relatively few studies have investigated the role of MMPs their inhibitors, tissue inhibitors (TIMPs), leukaemia invasion. This study examined two lines, K562 HL-60 showed that line was four times more invasive than line. expression MMP-2, matrilysin (MMP-7), MMP-9, TIMP-1, TIMP-2 TIMP-3 analysed. Both lines produced similar amounts MMP-9 TIMP-2. cells expressed TIMP-1 neither TIMP-3. Interestingly, only suggesting a potential for In vitro assays performed presence blocking antibody 40% reduction ability. data suggests plays an
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