Plasminogen Activation on Tumor Cell Surface and its Involvement in Human Leukemia

摘要: Publisher Summary This chapter focuses on the plasminogen activation tumor cell surface and its involvement in human leukemia. The function of activators (PAS) plasmin adult organism has been mainly related to fibrinolysis, tissue remodeling, migration, destruction. Associated with activity is dissolution blood clots, inflammation, dissemination, wound healing, angiogenesis, trophoblast invasion. In addition directly cleaving components extracellular matrix, able regulate various functions through prohormones latent growth factors. invasive capacity cells requires proteolytic activity; therefore, plasmin, together other tissue-destructive enzymes, implicated property metastasize. Both PAS bind surfaces, this allows generation at restricted areas cell-matrix interface. High levels urokinase activator (uPA) and/or inhibitor type 1, seem indicate an adverse prognosis for patients cancer, as was first shown case breast cancer. described include plasminogen, urokinase-type activator, tissue-type activator. Plasminogen regulated both by inhibitors plasmin. (PAIs) are specific, fast-acting PAS. Four known, PAI-1, PAI-2, PAI-3, PAI-4 (protease nexin). α 2 MR, which identical low-density lipoprotein receptor protein (LRP), reported mediate internalization degradation tPA, tPA-PAI-1 complexes, uPA-PAL1 uPA-protease nexin complexes. Although needed process matrix destruction, it still unknown whether uPA or merely antigen uPAR involved migration.