Exacerbation of metastatic disease shortly after administration of tamoxifen in ER negative advanced breast carcinoma. A case report.

摘要: In a patient with long untreated slow-growing osteoblastic bone metastases from an ER/PgR negative breast carcinoma, new metastatic sites in many lymphnodes pleura and massively liver have been observed 4 weeks after receiving tamoxifen. Cause-effect relationship between administration of the drug this unusually rapid spreading disease may be considered only as hypothesis, it is based wholly on clinical outcome. However, reporting any exacerbation cancer apparently induced by tamoxifen, even if anecdotal, advisable.