Identification of Differentially Expressed Genes in Lung Tissues of Nickel-Exposed Rats Using Suppression Subtractive Hybridization
作者： Jing Zhang , Jun Zhang , Yingying Fan , Lihong Liu , Mengjie Li
DOI: 10.1007/S12011-010-8898-4
关键词:
摘要: Occupational exposure to nickel compound, such as refining, electroplating, and in conjunction with other metals, is harmful the health, causing respiratory distress, lung nasal cancer. In this work, different gene expression patterns of tissues from nickel-exposed rats controls were investigated. The suppression subtractive hybridization (SSH) method was used generate two subtracted cDNA libraries transcripts differentially expressed after inducing. Dot-blot hybridizations confirm differential ratios obtained SSH clones. Out 768 unique clones, which chosen randomly subtraction (384 each), 319 could be verified expressed. According blast screening functional annotation, 28% genes nickel-induced library related cell differentiation, whereas 21% driver oxygen transport. Two novel sequence tags (ESTs; NCBI Accession No. FC809414 FC809411) obtained. detected present study are probably important associated
springer.com
sci-hub.se 参考文章(36)
Naoya Shibayama, Hideki Morimoto, Teizo Kitagawa, Properties of chemically modified Ni(II)-Fe(II) hybrid hemoglobins. Ni(II) protoporphyrin IX as a model for a permanent deoxy-heme. Journal of Molecular Biology. ,vol. 192, pp. 331- 336 ,(1986) , 10.1016/0022-2836(86)90368-2
Konstantin Salnikow, Max Costa, Vika Voitkun, Xi Huang, Min Gao, Altered Oxidative Stress Responses in Nickel-resistant Mammalian Cells Cancer Research. ,vol. 54, pp. 6407- 6412 ,(1994)
Qin Li, Ting-Chung Suen, Hong Sun, Adriana Arita, Max Costa, Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway. Toxicology and Applied Pharmacology. ,vol. 235, pp. 191- 198 ,(2009) , 10.1016/J.TAAP.2008.12.005
B.T. Sherwood, A.J. Colquhoun, D. Richardson, K.J. Bowman, K.J. O'Byrne, R.C. Kockelbergh, R.P. Symonds, J.K. Mellon, G.D.D. Jones, Carbonic anhydrase IX expression and outcome after radiotherapy for muscle-invasive bladder cancer. Clinical Oncology. ,vol. 19, pp. 777- 783 ,(2007) , 10.1016/J.CLON.2007.06.014
Alison S. Williams, Paul R. Eynott, Sum-Yee Leung, Puneeta Nath, Ray Jupp, George T. De Sanctis, Robert Resnick, Ian M. Adcock, Kian Fan Chung, Role of cathepsin S in ozone-induced airway hyperresponsiveness and inflammation. Pulmonary Pharmacology & Therapeutics. ,vol. 22, pp. 27- 32 ,(2009) , 10.1016/J.PUPT.2008.11.002
Meng-Chun Yang, Yuhong Guo, Chia-Chi Liu, Jonathan C. Weissler, Yih-Sheng Yang, The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells Biochemical and Biophysical Research Communications. ,vol. 344, pp. 484- 490 ,(2006) , 10.1016/J.BBRC.2006.03.158
S. Süer, H. Sönmez, İ Karaaslan, H. Baloğlu, E. Kökoğlu, Tissue sialic acid and fibronectin levels in human prostatic cancer Cancer Letters. ,vol. 99, pp. 135- 137 ,(1996) , 10.1016/0304-3835(95)04084-6
Natacha Rocks, Geneviève Paulissen, Mehdi El Hour, F Quesada, Céline Crahay, Maud Gueders, Jean-Michel Foidart, Agnès Noel, Didier Cataldo, Emerging roles of ADAM and ADAMTS metalloproteinases in cancer Biochimie. ,vol. 90, pp. 369- 379 ,(2008) , 10.1016/J.BIOCHI.2007.08.008
M. Goldberg, S. Dunning, H. Bunn, Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein Science. ,vol. 242, pp. 1412- 1415 ,(1988) , 10.1126/SCIENCE.2849206
Frieder W. Scheller, Nikitas Bistolas, Songqin Liu, Michael Jänchen, Martin Katterle, Ulla Wollenberger, Thirty years of haemoglobin electrochemistry Advances in Colloid and Interface Science. ,vol. 116, pp. 111- 120 ,(2005) , 10.1016/J.CIS.2005.05.006