The Three Ps: Psychiatry, Pharmacy, and Pharmacogenomics, a Brief Report From New Zealand.

摘要: We describe a case series of 22 individuals who were referred to our laboratory by pharmacist based in mental health hospital, for pharmacogenetic analysis due severe or unexpected adverse drug reactions (ADR) psychiatric medication. The participants genotyped common variation the CYP2D6, CYP2C19 and CYP2C9 genes, using Sanger sequencing. tested variants these genes as they have strongest evidence with respect altering pharmacokinetics commonly prescribed medicine. Looking specifically at subset 18 European study participants, we observed high but non-significant rate variants, compared allele frequency from unselected population samples. For CYP2D6 an elevated both poor (17%) intermediate (33%) metabolizers when previously reported frequencies (6% 12% respectively). increased ultra-rapid expected (21% 4% While sample size is major limitation this brief report, can conclude that patients antidepressant antipsychotic drugs selected specialist appear relatively genetic pharmacogenes known affect drugs. selective application such tests clinical pharmacists may be valuable approach clarify basis unusual responses medication, guide ongoing prescribing decisions group patients.