Clinical aspects of growth hormone deficiency in adults.

摘要: I. Introduction GRADUALLY it is being realized that GH may have important physiological functions in adult man. Until recently, was only used to treat short statured children with established deficiency (GHD), and remains common practice discontinue replacement therapy when final height reached. From a point of view, questionable whether this approach appropriate since well known secretion persists throughout life (1–5). Daily production reaches its maximum during puberty (3–5). Thereafter, the rate gradually decreases age (3). Recently, several studies shown GHD adults associated abnormalities body composition (6–14), metabolic derangements (15–17), suboptimal physical performance (18–20). Since recombinant technology has solved limitations supply, policies concerning man now be reconsidered. The performed uniformly suggest these patien...