Dose Titration and Monitoring GH Treatment in the Adult

摘要: Increasingly, growth hormone (GH) replacement is being offered to adults with severe GH deficiency (GHD). Initial reports of the benefits therapy (23, 35) in adult GHD population were based on trials using doses comparable those which had been used for years paediatric practice. Whilst most studies demonstrated therapy, two observations suggested that these supraphysiological. Firstly, compared children, incidence side effects was greater and often responded a dose reduction. Salomon et al (35) reported fluid retention, arthralgia or myalgia more than half patients they treated 0.07 IU/kg/day GH. Furthermore review by De Boer (10) several published between 1989 1993 61% at above 2.5 IU/ m2/day effects. Secondly proportion IGF-1 levels normal range suggesting over-treatment. In Moller (27) dose-dependent rise during treatment adults, markedly elevated following 4 More recent have confirmed raised receiving high (8,11,27).