Serum insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and the acid-labile subunit as serum markers of body composition during growth hormone (GH) therapy in adults with GH deficiency.

摘要: Serum levels of insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), the acid-labile subunit (ALS), insulin, and IGFBP-1 were evaluated as indicators body composition during GH replacement therapy in 20 GH-deficient patients (9 women 11 men), aged 22–57 yr, with IGF-I below −2 sd. The mean dose was 0.128 ± 0.003 IU/kg·week first month thereafter 0.23 0.01 IU/kg·week, divided into daily doses (0.7–4.3 IU/day). IGF-I, ALS, IGFBP-3 above normal range reached seven, five, three subjects, respectively, after 12 months therapy. ALS levels, but not correlated total (r = 0.676; P 0.001 r 0.631; P= 0.003). increase lean mass (LBM) measured by dual energy x-ray absorptiometry 3.0 0.5 kg (P < 0.001). At months, LBM values significantly to 0.718; 0.001), or levels. No correla...