Nrf2 signaling and cell survival.
作者： Suryakant K. Niture , James W. Kaspar , Jun Shen , Anil K. Jaiswal
DOI: 10.1016/J.TAAP.2009.06.009
关键词:
摘要: Nrf2:INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves an adaptor to link Nrf2 the ubiquitin ligase Cul3-Rbx1 complex that ubiquitinate and degrade Nrf2. Under basal conditions, cytosolic INrf2/Cul3-Rbx1 is constantly degrading When cell encounters stress dissociates from translocates into nucleus. Oxidative/electrophilic induced modification of INrf2Cysteine151 and/or protein kinase C (PKC)-mediated phosporylation Nrf2Serine40 controls release followed by stabilization nuclear translocation binds antioxidant response element (ARE) activates myriad genes protect cells against neoplasia. A delayed GSK-3β phosphorylates Fyn at unknown threonine residue(s). Phosphorylated nucleus Nrf2Tyrosine568 leads export degradation Prothymosin-α mediated also degrades The both in cytosol compartments rapidly brings down its levels normal resulting suppression downstream gene expression. An autoregulatory loop between their cellular abundance. regulates controlling transcription, it. In conclusion, switching on off combined with promoting them activation/deactivation defensive leading protection adverse effects oxidative electrophilic promote survival.
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