Glucose consumption by transplanted tumors in vivo.

摘要: Summary The relationship between availability and utilization of glucose production lactate was studied in vivo Walker carcinoma 256, Hepatoma 5123, Fibrosarcoma 4956 transplanted rats. tumors utilized 0.96, 0.55, 0.45 gm glucose/hr/100 wet tumor weight, respectively, corresponding to 28%, 23%, 32% the amount supplied. About 35% consumed eliminated as regardless type. In normoglycemia, glycolyzed directly related available which decreased per unit weight size increased. During hyperglycemia, produced either by dextrose injections or diabetes, increased utilization. increase maximum during first few hours; then a “saturation” level reached. When hyperglycemia prolonged for several days, carcinomas hepatomas consistently about ½ more glucose; however, fibrosarcomas reduced their consumption 30%. Insulin did not improve normal diabetic Actually, overall because plasma host lowered insulin. Hypoglycemia 2-deoxy-d-glucose consumption, were unable compensate this decrease removing from blood. vascular walls neoplastic vessels maintained sharp concentration difference interstitial fluid, with fluid surrounding cells containing only mg percent free practically all passing through being rapidly consumed. disappeared compartments had equal concentrations glucose. Normo- hypoglycemia restored gradient compartment. time needed complete restoration longer after hyperglycemia. regulation transfer wall is postulated.