Carnitine and acylcarnitine profiles in dried blood spots of patients with acute myocardial infarction
作者： Haseeb Ahmad Khan , Abdullah Saleh Alhomida , Halima Al Madani , Samia Hasan Sobki , None
DOI: 10.1007/S11306-013-0505-1
关键词:
摘要: Earlier studies have suggested an important role of carnitine pathway in cardiovascular pathology. However, the redistribution and acylcarnitine pools, as a result altered metabolism, is not clearly known patients with acute myocardial infarction (AMI). We compared profiles 65 AMI patients, including 26 ST-elevated (STEMI) 39 non-ST-elevated (NSTEMI), 28 chest pain 154 normal controls. The levels acylcarnitines blood spots were determined using LC-MS/MS. Total free significantly higher all patient groups following order: STEMI > NSTEMI pain. short- medium-chain groups. Among long-chain acylcarnitines, C14:2 C16:1 increased NSTEMI. ratio to short-chain or was decreased STEMI, however significant increase observed In conclusion, alterations indicate possibility impaired homeostasis ischemic myocardium. clinical implications these findings for risk screening diagnosis prognosis require additional follow-up on large number patients. also suggest that dual-marker strategy (longer plasma half-life) combination troponin (shorter could be more promising biomarker stratification
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sci-hub.se 参考文章(69)
P. Cascone, E. Nastro Siniscalchi, Guido Gabriele, Paolo Gennaro, Trigeminal and facial schwannoma: a case load and review of the literature European Review for Medical and Pharmacological Sciences. ,vol. 16, pp. 8- 12 ,(2012)
Steven C. Hendrickson, James D. St. Louis, James E. Lowe, Salah Abdel-aleem, Free fatty acid metabolism during myocardial ischemia and reperfusion. Molecular and Cellular Biochemistry. ,vol. 166, pp. 85- 94 ,(1997) , 10.1023/A:1006886601825
Richard Webel, Subrata Kar, Fish oil supplementation & coronary artery disease: does it help? Missouri medicine. ,vol. 109, pp. 142- 145 ,(2012)
F. Burzotta, F. Buccelletti, A. Gallo, M. Montalto, M. Covino, B. Simeoni, L. Carbone, N. Gentiloni Silveri, Reduced performance of Troponin T for acute coronary syndromes diagnosis in the elderly and very elderly patients: a retrospective study of 2688 patients. European Review for Medical and Pharmacological Sciences. pp. 8- 15 ,(2012)
Lamanna F, Boem A, Bigalli A, Davini P, Controlled study on L-carnitine therapeutic efficacy in post-infarction. Drugs Under Experimental and Clinical Research. ,vol. 18, pp. 355- 365 ,(1992)
Yu Cao, Yun-xiao Wang, Cheng-juan Liu, Le-xin Wang, Zhi-wu Han, Chun-bo Wang, Comparison of pharmacokinetics of L-carnitine, Acetyl-L-carnitine and Propionyl-Lcarnitine after single oral administration of L-carnitine in healthy volunteers Clinical and Investigative Medicine. ,vol. 32, pp. 13- 19 ,(2009) , 10.25011/CIM.V32I1.5082
Paolo Felaco, Mario Bonomini, Andrea Urbani, Claudia Rossi, Mirco Zucchelli, Luigi Amoroso, Domenico Ciavardelli, Vittorio Sirolli, Carmine Di Ilio, Paolo Sacchetta, Sergio Bernardini, Augusto Di Castelnuovo, Arduino Arduini, Toward personalized hemodialysis by low molecular weight amino-containing compounds: future perspective of patient metabolic fingerprint. Blood Transfusion. ,vol. 10, pp. 78- 88 ,(2012) , 10.2450/2012.012S
Kyaw Thu Moe, Philip Wong, Current trends in diagnostic biomarkers of acute coronary syndrome. Annals Academy of Medicine Singapore. ,vol. 39, pp. 210- 215 ,(2010)
P. RIZZON, G. BIASCO, M. DI BIASE, F. BOSCIA, U. RIZZO, F. MINAFRA, A. BORTONE, N. SILIPRANDI, A. PROCOPIO, E. BAGIELLA, M. CORSI, High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects European Heart Journal. ,vol. 10, pp. 502- 508 ,(1989) , 10.1093/OXFORDJOURNALS.EURHEARTJ.A059519
C R Roe, D S Millington, D A Maltby, T P Bohan, C L Hoppel, L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia. Journal of Clinical Investigation. ,vol. 73, pp. 1785- 1788 ,(1984) , 10.1172/JCI111387