Feline Oral Squamous Cell Carcinoma: Clinical Manifestations and Literature Review.

作者: Ozgur Bilgic , Lili Duda , Melissa D. Sánchez , John R. Lewis

DOI: 10.1177/089875641503200104

关键词:

摘要: Squamous cell carcinoma (SCC) is the most commonly encountered malignant oral tumor in cats. The etiology of this locally invasive likely multifactorial. Several risk factors have been identified, including use flea collars, and a history feeding canned food tuna. Clinical signs vary depending on location. arises from gingiva mucosa maxilla, mandible, tongue, sublingual area, or tonsillar region. Maxillary SCC presents clinically as an ulcerative lesion, whereas mandibular proliferative, expansile, firm. Lingual/sublingual may be ulcerative, necrotic, infiltrative, proliferative. In general, feline neoplasm regardless its Surgery, radiation therapy, chemotherapy combinations thereof attempted with rarely satisfactory response. Currently, cures are obtained only small subset cats whose tumors amenable to complete resection, where resection microscopic residual disease followed by definitive therapy. A multimodal treatment approach offers best chance success. For advanced disease, palliative care improve patients' quality life, albeit transiently. Sequelae associated progression local tissue destruction often result euthanasia patients SCC.

参考文章(83)
Bradley Rl, MacEwen Eg, Loar As, Mandibular resection for removal of oral tumors in 30 dogs and 6 cats. Javma-journal of The American Veterinary Medical Association. ,vol. 184, pp. 460- ,(1984)
John R. Lewis, Thomas G. O'Brien, Katherine A. Skorupski, Erika L. Krick, Alexander M. Reiter, Michael W. Jennings, Carrie H. Jurney, FS Shofer, Karin U. Sorenmo, Polyamine inhibitors for treatment of feline oral squamous cell carcinoma: a proof-of-concept study. Journal of Veterinary Dentistry. ,vol. 30, pp. 140- 145 ,(2013) , 10.1177/089875641303000301
M K Klein, J L Stone, E J Walder, C C Willauer, C A Hutson, Treatment of mandibular squamous cell carcinoma in cats by use of mandibulectomy and radiotherapy: seven cases (1987-1989). Javma-journal of The American Veterinary Medical Association. ,vol. 201, pp. 777- 781 ,(1992)
GK Ogilvie, AS Moore, JE Obradovich, RE Elmslie, DM Vail, RC Straw, MD Salmon, MK Klein, SW Atwater, PE Ciekot, SM LaRue, AE Peaston, SJ Withrow, TOXICOSES AND EFFICACY ASSOCIATED WITH ADMINISTRATION OF MITOXANTRONE TO CATS WITH MALIGNANT TUMORS Javma-journal of The American Veterinary Medical Association. ,vol. 202, pp. 1839- 1844 ,(1993)
Arno Buecker, Axel Schmachtenberg, Thaddeus Stopinski, Michael Eble, Sylvia Kinzel, Thomas Jansen, Johannes Koch, Hans-Peter Treusacher, Sven Hein, Wernen Küpper, Hypofractionated radiation therapy for the treatment of malignant melanoma and squamous cell carcinoma in dogs and cats Berliner Und Munchener Tierarztliche Wochenschrift. ,vol. 116, pp. 134- 138 ,(2003)
L. Marconato, J. Buchholz, M. Keller, G. Bettini, P. Valenti, B. Kaser-Hotz, Multimodal therapeutic approach and interdisciplinary challenge for the treatment of unresectable head and neck squamous cell carcinoma in six cats: a pilot study. Veterinary and Comparative Oncology. ,vol. 11, pp. 101- 112 ,(2013) , 10.1111/J.1476-5829.2011.00304.X
Sarah H. O’Neill, Kimberly M. Newkirk, Eman A. Anis, Rupal Brahmbhatt, Linda A. Frank, Stephen A. Kania, Detection of human papillomavirus DNA in feline premalignant and invasive squamous cell carcinoma Veterinary Dermatology. ,vol. 22, pp. 68- 74 ,(2011) , 10.1111/J.1365-3164.2010.00912.X
J. Fidel, J. Lyons, C. Tripp, R. Houston, B. Wheeler, A. Ruiz, Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats. Journal of Veterinary Internal Medicine. ,vol. 25, pp. 504- 510 ,(2011) , 10.1111/J.1939-1676.2011.0721.X
Leigh A. Lamont, Adjunctive Analgesic Therapy in Veterinary Medicine Veterinary Clinics of North America-small Animal Practice. ,vol. 38, pp. 1187- 1203 ,(2008) , 10.1016/J.CVSM.2008.06.002