Treatment of oral squamous cell carcinoma with accelerated radiation therapy and concomitant carboplatin in cats.

摘要: Background: Feline oral squamous cell carcinoma (SCC) carries a very poor prognosis with traditional treatments. Hypothesis/Objectives: To examine the effectiveness of adding carboplatin to previously published accelerated radiation protocol in treatments SCC cats. Animals: Thirty-one cases cats. Tumor sites included lingual (n = 9), mandible 10), maxilla 7), tonsil 4), and cheek 1). Methods: Prospective trial using planned consisting 14 fractions 3.5 Gy given within 9-day period addition at 90–100 mg/m2 on day 1 4.5. Treatments were twice daily 6-hour delay between treatments. All cats presenting without evidence distant metastasis eligible. Results: Median survival for all was 163 days (range 53–770 days) mean 319 ± 53 significant predictors being site (P= .004) whether there complete response 30 .001). Cats tumors origin or responded best therapy long-term survivors 724 median had not been reached because continued 4 cats. Conclusions Clinical Importance: This offers an aggressive yet tolerable treatment that might offer improved as compared reported The tonsillar has previously.