A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age
作者： L Chang , PL Lee , CT Yiannoutsos , T Ernst , CM Marra
DOI: 10.1016/J.NEUROIMAGE.2004.07.067
关键词:
摘要: Objective: Differences in diagnostic criteria and methods have led to mixed results regarding the metabolite pattern of HIV-associated brain injury relation neurocognitive impairment. Therefore, a multicenter MRS consortium was formed evaluate neurometabolites HIV patients with or without cognitive Methods: Proton magnetic resonance spectroscopy (MRS) at short-echo time (30 ms) assessed frontal white matter, basal ganglia, parietal cortex 100 [61 AIDS dementia complex (ADC) 39 neuroasymptomatic (NAS)] 37 seronegative (SN) controls. Results: Compared SN, NAS had higher glial marker myoinositol-to-creatine ratio (MI/Cr) matter (multivariate analyses, adjusted P = 0.001), while ADC showed further increased MI/Cr ganglia (both
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