Phenotype of peripheral blood leukocytes and survival of patients with metastatic colorectal cancer
作者： P. Vesely , M. Touskov , B. Melichar
DOI: 10.5301/JBM.2008.863
关键词:
摘要: Immune dysfunction is prevalent in metastatic cancer. Few patients with colorectal cancer metastases are cured, and among the strategies aimed at improving therapeutic results cancer, immunotherapy being increasingly investigated. We evaluated retrospectively prognostic significance of peripheral blood leukocytes 59 The relative numbers CD3+, CD3+CD4+, CD3+CD8+, NK (CD3-CD16+CD56+), CD3+DR+, CD3+CD25+, CD3+CD69+, CD19+, CD19+CD23+, CD8+CD28+, CD8-CD28+, CD8+CD57+, CD14+DR+ CD14+CD16+ were analyzed by two-color flow cytometry. A three-step approach was adopted to identify predictors prognosis using regression analysis. Based on univariate survival analysis, absolute number white cells, NK/CD3+CD69+ NK/white cell count ratios significant indicators prognosis. In multivariate analysis a model obtained single parameter, ratio, predicting 10-15% power regression. present indicate that ratio may be an independent variable overall tested prospective studies.
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