Concise review: the immune status of mesenchymal stem cells and its relevance for therapeutic application.
作者： Shoshan Knaän-Shanzer
DOI: 10.1002/STEM.1568
关键词:
摘要: Multipotentiality and anti-inflammatory activity, the two main properties of mesenchymal stem cells (MSCs), underlie their therapeutic prospective. During past decade, numerous studies in animal models clinical trials explored potential MSCs treatment diseases associated with tissue regeneration inflammatory control. Other qualities MSCs: ready accessibility bone marrow fat rapid expansion culture make use patients' own feasible. The prevailing belief that are nonimmunogenic encouraged unrelated donor immune-competent recipients. data emerging from performed immune-incompatible for a wide-range human show, however, conflicting results cast doubt on immune privileged status MSCs. Our analysis preclinical literature this review is aimed to gain better understanding Emphasis was laid applications enhancement repair absence immune-suppressive therapy. Stem Cells 2014;32:603–608
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