Preparing Patients for Radioiodine Treatment: Increasing Thyroid Cell Uptake and Accelerating the Excretion of Unbound Radioiodine

摘要: The therapeutic application of radioiodine 131I in postoperative ablation the remaining thyroid tissue, as well treatment recidivism and/or local and remote metastases differentiated carcinoma has been a part clinical practice for over 50 years. It is regular segment standard procedure it comes recommended by number authorities field (American Association Clinical Endocrinologists/Associatione Medici Endocrinologi [AACE/AME], 2006; Cooper et al., Pacini Society Nuclear Medicine [SNM], 2006, British Thyroid [BTA], 2007; Dietlein Luster 2008; National Comprehensive Cancer Network [NCCN], 2010;). Certain differences opinion on subject are concerned only with dose that applied, whether radioactive iodine therapy should be utilized lower risk patients (ȃうаせけぬさая&Шаせてふちへ, 1981; Haq 2004; RingelL Gheriani, 2006). Several decades experience have shown indisputable beneficial effects administration adjuvant therapy. However, there can certain adverse effects, beside ones, which consequence radiation damage to other tissues organs. organs most exposed harmful effect salivary glands, nasolacrimal ducts, stomach epithelium, kidneys, bladder wall, colon, gonads, bone marrow, etc. But, long-term follow-up studies report very low secondary malignancies survivors (Rubino 2003; Brown 2008). Howewer, meta-analysis two large multicenter showed second was significantly increased relative cancer not treated RAI (Sawka 2009). related 2003), Cumulative activities above 500–600 mCi associated significant increase risk. There appears an breast women (Brown Sandeep Chen 2001). unclear this due therapy, screening bias or factors.