Plasma glucose, insulin, and glucagon before and after long-term overfeeding in identical twins.

摘要: Plasma glucose, insulin, and glucagon levels were measured before after long-term overfeeding (4.2 MJ/d during a 100-day period) in 24 lean adults (12 pairs of monozygotic twins). Fasting plasma significantly increased by overfeeding. During 75-g oral glucose tolerance test (OGTT), no major alteration was observed insulin area under the curve increased. meal test, areas The pre-overfeeding values for (fasting areas) not correlated with gains body weight fat mass. However, fasting positively abdominal visceral femoral fat. changes OGTT total subcutaneous fat, even adjustment gain. Significant twin intrapair similarity These results indicate that (1) response to overfeeding, both are increased; (2) initial do predict but related indicators topography; (3) represent an important correlate overfeeding; (4) genotype could be determinant responses prolonged positive-energy-balance period.