Cyclometalated Iridium(III) Complexes as Mitochondria‐targeting Photosensitizers against Cisplatin‐resistant Cells†

Aditi Jhaveri, Vladimir Torchilin, Intracellular delivery of nanocarriers and targeting to subcellular organelles Expert Opinion on Drug Delivery. ,vol. 13, pp. 49- 70 ,(2016) , 10.1517/17425247.2015.1086745

Wen Zhou, Xiaoyong Wang, Ming Hu, Chengcheng Zhu, Zijian Guo, A mitochondrion-targeting copper complex exhibits potent cytotoxicity against cisplatin-resistant tumor cells through multiple mechanisms of action Chemical Science. ,vol. 5, pp. 2761- 2770 ,(2014) , 10.1039/C4SC00384E

Hsueh-Lin Lu, Wei-Jhe Syu, Nobuhoro Nishiyama, Kazunori Kataoka, Ping-Shan Lai, Dendrimer phthalocyanine-encapsulated polymeric micelle-mediated photochemical internalization extends the efficacy of photodynamic therapy and overcomes drug-resistance in vivo Journal of Controlled Release. ,vol. 155, pp. 458- 464 ,(2011) , 10.1016/J.JCONREL.2011.06.005

Jennifer Q. Kwong, Jeffery D. Molkentin, Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart Cell Metabolism. ,vol. 21, pp. 206- 214 ,(2015) , 10.1016/J.CMET.2014.12.001

Divya Pathania, Melissa Millard, Nouri Neamati, Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆ Advanced Drug Delivery Reviews. ,vol. 61, pp. 1250- 1275 ,(2009) , 10.1016/J.ADDR.2009.05.010

Noemi Rubio, Isabelle Coupienne, Emmanuel Di Valentin, Ingeborg Heirman, Johan Grooten, Jacques Piette, Patrizia Agostinis, Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species Autophagy. ,vol. 8, pp. 1312- 1324 ,(2012) , 10.4161/AUTO.20763

Roberto Padilla, José A. Rodriguez-Corrales, Lauren E. Donohoe, Brenda S. J. Winkel, Karen J. Brewer, A new class of Ru(II) polyazine agents with potential for photodynamic therapy Chemical Communications. ,vol. 52, pp. 2705- 2708 ,(2016) , 10.1039/C5CC08682E

Toshitada Yoshihara, Masahiro Hosaka, Motoki Terata, Kazuki Ichikawa, Saori Murayama, Asami Tanaka, Masanobu Mori, Hideyuki Itabashi, Toshiyuki Takeuchi, Seiji Tobita, Intracellular and in Vivo Oxygen Sensing Using Phosphorescent Ir(III) Complexes with a Modified Acetylacetonato Ligand Analytical Chemistry. ,vol. 87, pp. 2710- 2717 ,(2015) , 10.1021/AC5040067

Richard Lincoln, Lars Kohler, Susan Monro, Huimin Yin, Mat Stephenson, Ruifa Zong, Abdellatif Chouai, Christopher Dorsey, Robie Hennigar, Randolph P. Thummel, Sherri A. McFarland, Exploitation of Long-Lived 3IL Excited States for Metal–Organic Photodynamic Therapy: Verification in a Metastatic Melanoma Model Journal of the American Chemical Society. ,vol. 135, pp. 17161- 17175 ,(2013) , 10.1021/JA408426Z

Kai Xiong, Yu Chen, Cheng Ouyang, Rui-Lin Guan, Liang-Nian Ji, Hui Chao, Cyclometalated iridium(III) complexes as mitochondria-targeted anticancer agents Biochimie. ,vol. 125, pp. 186- 194 ,(2016) , 10.1016/J.BIOCHI.2016.03.013