Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice

摘要: Using a Cre-lox-based genetic labeling technique, we have recently discovered parity-induced mammary epithelial subtype that is abundant in nonlactating and nonpregnant, parous females. These cells serve as alveolar progenitors subsequent pregnancies, transplantation studies revealed they possess features of multipotent such self-renewal the capability to contribute ductal morphogenesis. Here, report these are cellular targets for transformation MMTV-neu transgenic mice exhibit accelerated tumorigenesis multiparous animals. The selective ablation this reduces onset transgenics. There is, however, experimental evidence suggest may not be only other MMTV-promoter-based strains. In particular, heterogeneous MMTV-wnt1 lesions predominantly express differentiation marker Nkcc1 absent MMTV-neu-derived tumors. Our observations support idea tumors originate from distinctly different subtypes selected MMTV-promoter-driven cancer models diverse oncogenes might exert discrete effects on particular subtypes.