Drosophila immune cell migration and adhesion during embryonic development and larval immune responses

作者: Aparna Ratheesh , Vera Belyaeva , Daria E Siekhaus

DOI: 10.1016/J.CEB.2015.07.003

关键词:

摘要: The majority of immune cells in Drosophila melanogaster are plasmatocytes; they carry out similar functions to vertebrate macrophages, influencing development as well protecting against infection and cancer. Plasmatocytes, sometimes referred with the broader term hemocytes, migrate widely during embryonic cycle larvae between sessile circulating positions. Here we discuss similarities plasmatocyte developmental migration its that considering recent controversy regarding PDGF/VEGF related ligands. We also examine findings on significance adhesion for embryo, proliferation, trans-differentiation, tumor responses larva. spotlight parallels throughout responses.

参考文章(84)
Julia B. Cordero, Juan P. Macagno, Rhoda K. Stefanatos, Karen E. Strathdee, Ross L. Cagan, Marcos Vidal, Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter Developmental Cell. ,vol. 18, pp. 999- 1011 ,(2010) , 10.1016/J.DEVCEL.2010.05.014
Christine Kocks, Ju Hyun Cho, Nadine Nehme, Johanna Ulvila, Alan M. Pearson, Marie Meister, Charles Strom, Stephanie L. Conto, Charles Hetru, Lynda M. Stuart, Thilo Stehle, Jules A. Hoffmann, Jean-Marc Reichhart, Dominique Ferrandon, Mika Rämet, R. Alan B. Ezekowitz, Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila Cell. ,vol. 123, pp. 335- 346 ,(2005) , 10.1016/J.CELL.2005.08.034
Andrew D Luster, Ronen Alon, Ulrich H von Andrian, Immune cell migration in inflammation: present and future therapeutic targets Nature Immunology. ,vol. 6, pp. 1182- 1190 ,(2005) , 10.1038/NI1275
D. T. Babcock, A. R. Brock, G. S. Fish, Y. Wang, L. Perrin, M. A. Krasnow, M. J. Galko, Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 10017- 10022 ,(2008) , 10.1073/PNAS.0709951105
R. Markus, B. Laurinyecz, E. Kurucz, V. Honti, I. Bajusz, B. Sipos, K. Somogyi, J. Kronhamn, D. Hultmark, I. Ando, Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 4805- 4809 ,(2009) , 10.1073/PNAS.0801766106
Fiona J. Pixley, Macrophage Migration and Its Regulation by CSF-1. International Journal of Cell Biology. ,vol. 2012, pp. 501962- 501962 ,(2012) , 10.1155/2012/501962
R. A. Pagliarini, A genetic screen in drosophila for metastatic behavior Science. ,vol. 302, pp. 1227- 1231 ,(2004) , 10.1126/SCIENCE.1088474
Heather C Sears, Caleb J Kennedy, Paul A Garrity, Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis. Development. ,vol. 130, pp. 3557- 3565 ,(2003) , 10.1242/DEV.00586
Christian Schulz, Elisa Gomez Perdiguero, Laurent Chorro, Heather Szabo-Rogers, Nicolas Cagnard, Katrin Kierdorf, Marco Prinz, Bishan Wu, Sten Eirik W. Jacobsen, Jeffrey W. Pollard, Jon Frampton, Karen J. Liu, Frederic Geissmann, A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells Science. ,vol. 336, pp. 86- 90 ,(2012) , 10.1126/SCIENCE.1219179
A. Braun, J. A. Hoffmann, M. Meister, Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 14337- 14342 ,(1998) , 10.1073/PNAS.95.24.14337