Ginkgo biloba Extract Prevents Female Mice from Ischemic Brain Damage and the Mechanism Is Independent of the HO1/Wnt Pathway.

摘要: It is well known that gender differences exist in experimental or clinical stroke with respect to brain damage and loss of functional outcome. We have previously reported neuroprotective properties Ginkgo biloba/EGb 761® (EGb 761) transient permanent mouse models ischemia using male mice, the mechanism action was attributed upregulation heme oxygenase 1 (HO1)/Wnt pathway. Here, we sought investigate whether EGb 761’s protective effect ovariectomized female mice following also mediated by HO1/Wnt Female were (OVX) remove estrogen treated 761 for 7 days prior inducing middle cerebral artery occlusion (pMCAO) allowed survive an additional days. At day 8, animals sacrificed, brains harvested infarct volume analysis, western blots, immunohistochemistry. The OVX showed significantly lower size as compared Veh/OVX animals. treatment inhibited apoptosis preventing caspase-3 cleavage blocking extrinsic apoptotic pretreatment enhanced neurogenesis group upregulated androgen receptor expression no changes signaling. These results suggest prevented improving grip strength neurological deficits, not through but via