Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries

摘要: Purpose: The epidemiology of colorectal carcinoma is well known to differ among countries but the molecular characteristics are usually assumed be similar. International differences in pathology have not been studied extensively implications for management patients different and immigrant patients. Experimental Design: We evaluated CpG island methylator phenotype pathway characterized by concordant methylation gene promoters that often silences transcription genes, microsatellite instability pathway, K- ras p53 status 247 carcinomas from three selected Middle Eastern Egypt, Jordan, Turkey. Results: Colorectal Egypt had lowest frequencies methylation. In multinomial logistic regression analysis, Jordanian more frequently involving p16 tumor suppressor (odds ratio, 3.5; 95% confidence interval, 1.2-10.6; P = 0.023) MINT31 locus 2.3; 1.0-5.1; 0.041). proto-oncogene was mutated Turkey 2.9; 1.2-6.7; 0.016), overexpression common both Turkish than Egyptian cases 2.5; 1.2-5.5; 0.019; odds 3.6; 1.8-7.1; 0.0003, respectively). findings were most similar those reported Western cases. Conclusions: differing patterns mutation indicate dissimilar pathogenesis, probably reflecting environmental exposures. These could affect prevention strategies, therapeutic efficacy, transferability clinical trial results.