In Vitro and in Vivo Biodurability of a Compliant Microporous Vascular Graft

摘要: Polyurethanes have unique mechanical and biologic properties that make them ideal for many implantable devices. However, certain polyurethanes are affected by some in vivo degradation mechanisms. For example, poly(ester)urethanes subject to hydrolytic no longer used long-term implanted Poly(ether)urethanes while hydrolytically stable, oxidative several forms, including environmental stress cracking metal ion oxidation. We developed a second-generation poly(carbonate)urethane with superior biostability. This material has been fabricated our patented method into small diameter microporous vascular grafts. evidenced the biodurability of graft vitro qualification tests which compared traditional poly(ether)urethane. also proven be biodurable experimental implants up twenty months duration evidence hydrolysis or (ESC).