Cellular and Molecular Biomarkers for Risk Assessment of Colorectal cancer

摘要: The detection of Colorectal Cancer (CRC), at early stages, is one the proven strategies resulting in a higher cure rate. In recent years, several studies have appeared identifying potential cancer markers serum, plasma and stool an attempt to improve actual screening procedures. Thus, aim study was (1) Evaluate MN frequency, (2) ultrafiltrate capacity induce formation, (3) SEPT9 NOTCH3 promoter methylation profile peripheral blood lymphocytes from subjects resulted positive fecal occult test examined by colonoscopy. frequency significantly with histological diagnosis CRC adenoma than control (p ≤ 0.001 p 0.01, respectively). About, CF-MN analysis, statistically significant difference observed between 0.05). On other hand, status lower controls; additionally, 0.01). results obtained allow conclude that varies according pathologic and, together variables, valid biomarker for risk. Additionally, patients affected not only serve as oxidative stress but also genetic damage correlated carcinogenic process verifies colon-rectum. status, level, hystopathological changes colon-rectum, suggesting these genes could be reliable