CLASTOGENIC FACTORS AS POTENTIAL BIOMARKERS OF INCREASED SUPEROXIDE PRODUCTION

摘要: The formation of clastogenic factors (CF) and their damaging effects are mediated by superoxide, since superoxide dismutase is regularly protective. CF produced via stimulate the production monocytes neutrophils. This results in a selfsustaining longlasting process clastogenesis, which may exceed DNA repair system ultimately lead to cancer (Emerit, 1994). An increased risk indeed observed conditions accompanied formation. These include irradiated persons, patients with chronic inflammatory diseases, HIV-infected persons chromosomal breakage syndromes ataxia telangiectasia, Bloom’s syndrome Fanconi’s anemia. Biochemical analysis has identified lipid peroxidation products, arachidonic acid metabolites, nucleotides inosine cytokines, particular tumor necrosis factor alpha, as also stimulating components CF. Due chromosome effects, these oxidants can be detected classical cytogenetic techniques. Their synergistic action renders CF-test particularly sensitive for detection pro-oxidant state. Correlations were between other biomarkers oxidative stress such decreases total plasma thiols or increases TBARS chemiluminescence. disease activity, radiation exposure, suggest study monitoring conditions. useful biochemical markers intermediate endpoints evaluation promising antioxidant drugs. CF represents link inflammation carcinogenesis. Prophylactic use scavengers anticarcinogens therefore suggested.