EFFICIENT SYNTHESIS OF NATURAL (+)-COLLINUSIN USING CATALYTIC ASYMMETRIC HYDROGENATION WITH A CHIRAL BISPHOSPHINE-RHODIUM(I) COMPLEX

作者: Toshiaki MORIMOTO , Mitsuo CHIBA , Kazuo ACHIWA

DOI: 10.1248/CPB.37.3161

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摘要: (+)-Collinusin, a natural lignan lactone, has been synthesized by using the asymmetric hydrogenation of α-veratrylidenesuccinic acid half ester with (S, S)-MOD-DIOP-rhodium(I) complex catalyst as key reaction, and absolute configuration C-3 determined to be R__-.

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