Stereoselective Hydrogenation of CC Bonds: Application to Drug and Natural Product Synthesis

摘要: Asymmetric homogeneous hydrogenation is perhaps one of the most researched areas in catalysis; thus, it now used numerous innovative applications stereoselective syntheses many chiral pharmaceutical and natural products. Metal complexes, derived from transition metals, like Rh, Ru, Ir, so on, ligands (usually mono- or diphosphine ligands), are widely as catalysts asymmetric alkene a result their efficiency preparation enantiopure compounds with excellent atom economy. This chapter provides interesting examples enantio- diastereoselective CC bonds, highlighting utility these methods useful synthetic tools for construction stereogenic centers drug product syntheses. Keywords: hydrogen; asymmetric hydrogenation; alkene; hydrogenation; CC bond; stereoselective; synthesis; enantioselective; drug; natural product; rhodium; ruthenium; iridium; chiral ligand; C–H bond formation; S/C ratio; pharmaceutical