Local administration of prostaglandin E1 combined with silicone chamber improves peripheral nerve regeneration
作者： Alireza Najafpour , Rahim Mohammadi , Darab Faraji , Keyvan Amini
DOI: 10.1016/J.IJSU.2013.05.034
关键词:
摘要: The aim of this study was to assess the effect locally administered prostaglandin E1 on peripheral nerve regeneration and functional recovery. Sixty male healthy white Wistar rats were divided into four experimental groups (n = 15), randomly: In transected group (TC), left sciatic stumps fixed in adjacent muscle. treatment defect bridged using silicone graft (SIL/PE) filled with 10 μL E1. (SIL), phosphate-buffered saline alone. sham-operated (SHAM), exposed manipulated. Each subdivided three subgroups five animals each regenerated fibers studied 4, 8 12 weeks after surgery. Behavioral testing, study, gastrocnemius muscle mass morphometric indices confirmed faster recovery axons SIL/PE than SIL (p < 0.05). immunohistochemistry, location reactions S-100 clearly more positive that group. When loaded a graft, improved nerve. Local application
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