Leukemia Inhibitory Factor Signaling Is Required for Lung Protection during Pneumonia

作者: Lee J. Quinton , Joseph P. Mizgerd , Kristie L. Hilliard , Matthew R. Jones , Candice Y. Kwon

DOI: 10.4049/JIMMUNOL.1200256

关键词:

摘要: Lung infections represent a tremendous disease burden and a leading cause of acute lung injury. STAT3 signaling is essential for controlling lung injury during pneumonia. We …

参考文章(69)
Xuemei Lian, Yulin Qin, Shaikh Abu Hossain, Li Yang, Amanda White, Huan Xu, J. Michael Shipley, Tingyu Li, Robert M. Senior, Hong Du, Cong Yan, Overexpression of Stat3C in Pulmonary Epithelium Protects against Hyperoxic Lung Injury Journal of Immunology. ,vol. 174, pp. 7250- 7256 ,(2005) , 10.4049/JIMMUNOL.174.11.7250
Rafia S. Al-Lamki, Jun Wang, Aviva M. Tolkovsky, J. Andrew Bradley, Jules L. Griffin, Sathia Thiru, Eddie C.Y. Wang, Eleanor Bolton, Wang Min, Paul Moore, Jordan S. Pober, John R. Bradley, TL1A Both Promotes and Protects from Renal Inflammation and Injury Journal of the American Society of Nephrology. ,vol. 19, pp. 953- 960 ,(2008) , 10.1681/ASN.2007060706
Isamu Hokuto, Machiko Ikegami, Mitsuhiro Yoshida, Kiyoshi Takeda, Shizuo Akira, Anne-Karina T. Perl, William M. Hull, Susan E. Wert, Jeffrey A. Whitsett, Stat-3 is required for pulmonary homeostasis during hyperoxia Journal of Clinical Investigation. ,vol. 113, pp. 28- 37 ,(2004) , 10.1172/JCI19491
Lee J. Quinton, Matthew R. Jones, Bryanne E. Robson, Benjamin T. Simms, Jeffrey A. Whitsett, Joseph P. Mizgerd, Alveolar Epithelial STAT3, IL-6 Family Cytokines, and Host Defense during Escherichia coli Pneumonia American Journal of Respiratory Cell and Molecular Biology. ,vol. 38, pp. 699- 706 ,(2008) , 10.1165/RCMB.2007-0365OC
Matthew R. Jones, Benjamin T. Simms, Michal M. Lupa, Mariya S. Kogan, Joseph P. Mizgerd, Lung NF-κB Activation and Neutrophil Recruitment Require IL-1 and TNF Receptor Signaling during Pneumococcal Pneumonia Journal of Immunology. ,vol. 175, pp. 7530- 7535 ,(2005) , 10.4049/JIMMUNOL.175.11.7530
Hee Kyung Jin, Ayato Takada, Yasuhiro Kon, Otto Haller, Tomomasa Watanabe, Identification of the Murine Mx2 Gene: Interferon-Induced Expression of the Mx2 Protein from the Feral Mouse Gene Confers Resistance to Vesicular Stomatitis Virus Journal of Virology. ,vol. 73, pp. 4925- 4930 ,(1999) , 10.1128/JVI.73.6.4925-4930.1999
Anna C. Zemke, Joshua C. Snyder, Brian L. Brockway, Jeffrey A. Drake, Susan D. Reynolds, Naftali Kaminski, Barry R. Stripp, Molecular staging of epithelial maturation using secretory cell-specific genes as markers. American Journal of Respiratory Cell and Molecular Biology. ,vol. 40, pp. 340- 348 ,(2009) , 10.1165/RCMB.2007-0380OC
Matthew R. Jones, Lee J. Quinton, Benjamin T. Simms, Michal M. Lupa, Mariya S. Kogan, Joseph P. Mizgerd, Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. The Journal of Infectious Diseases. ,vol. 193, pp. 360- 369 ,(2006) , 10.1086/499312
Jeremy P. McAleer, Jay K. Kolls, Mechanisms controlling Th17 cytokine expression and host defense Journal of Leukocyte Biology. ,vol. 90, pp. 263- 270 ,(2011) , 10.1189/JLB.0211099
Rodrigo Fernández-Valdivia, Ying Zhang, Sonia Pai, Michael L. Metzker, Armin Schumacher, l7Rn6 Encodes a Novel Protein Required for Clara Cell Function in Mouse Lung Development Genetics. ,vol. 172, pp. 389- 399 ,(2006) , 10.1534/GENETICS.105.048736