Neuroretinal Degeneration in HIV Patients Without Opportunistic Ocular Infections in the cART Era

摘要: Abstract Subtle structural and functional retinal abnormalities, termed ‘HIV-associated Neuroretinal Disorder (HIV-NRD)’, have been reported in HIV patients receiving combination antiretroviral therapy (cART), without infectious retinitis or any apparent fundus abnormalities otherwise. In this review, we provide an overview of studies investigating HIV-NRD opportunistic ocular infections the cART era, try to elucidate underlying mechanisms associated risk factors. Most focused on with severe immune-deficiency demonstrated that nadir CD4 counts <100 cells/μL are most at for neuroretinal damage, a thinner nerve fiber layer, subtle loss color vision and/or contrast sensitivity, visual field deficits, subnormal electrophysiological responses. contrast, alterations vascular calibers blood flow were not counts, but instead detectable viremia, suggesting role f...