Stimulation of Pancreatic Growth by Secretin, Caerulein, and Pentagastrin*
作者： ARTUR B. DEMBINSKI , LEONARD R. JOHNSON
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摘要: The primary hormonal regulators of pancreatic exocrine secretion are secretin and cholecystokinin. In addition, cholecystokinin is known to stimulate the growth pancreas. current study examines whether also alters by itself it influences trophic response caerulein, a structural functional homolog Rats were injected every 8 h for 7 days with either saline, (50 U/kg), caerulein (320 ng/kg), or combination above doses caerulein. After sacrificing animals, pancreas was isolated, in vitro incorporation [3H]thymidine into DNA measured. weighed, content RNA determined. Secretin administered alone both caused significant increases synthesis concentrations DNA. effects two hormones on total showed potentiation when combined. ...
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sci-hub.se 参考文章(27)
M Lehv, P J Fitzgerald, Pancreatic acinar cell regeneration. IV. Regeneration after resection. American Journal of Pathology. ,vol. 53, pp. 513- 535 ,(1968)
B. Carol, P. J. Fitzgerald, D. Perl, L. Herman, A. Roque, W. H. Marsh, C. Richards, L. Rosenstock, Pancreatic acinar cell regeneration. American Journal of Pathology. ,vol. 52, pp. 983- 1011 ,(1968)
Leonard R. Johnson, Paul Guthrie, Effect of cholecystokinin and 16,16-dimethyl prostaglandin E2 on RNA and DNA of gastric and duodenal mucosa. Gastroenterology. ,vol. 70, pp. 59- 65 ,(1976) , 10.1016/S0016-5085(76)80403-9
Giovanni Ceriotti, DETERMINATION OF NUCLEIC ACIDS IN ANIMAL TISSUES Journal of Biological Chemistry. ,vol. 214, pp. 59- 70 ,(1955) , 10.1016/S0021-9258(18)70943-5
Leonard R. Johnson, The trophic action of gastrointestinal hormones. Gastroenterology. ,vol. 70, pp. 278- 288 ,(1976) , 10.1016/S0016-5085(76)80024-8
B. Carol, P. J. Fitzgerald, K. Vinijchaikul, L. Rosenstock, Pancreatic acinar cell regeneration. 3. DNA synthesis of pancreas nuclei as indicated by thymidine-H3 autoradiography. American Journal of Pathology. ,vol. 52, pp. 1039- 1065 ,(1968)
Leonard R. Johnson, Lenard M. Lichtenberger, Edward M. Copeland, Stanley J. Dudrick, Gilbert A. Castro, Action of Gastrin on Gastrointestinal Structure and Function Gastroenterology. ,vol. 68, pp. 1184- 1192 ,(1975) , 10.1016/S0016-5085(75)80233-2
K. Burton, A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid Biochemical Journal. ,vol. 62, pp. 315- 323 ,(1956) , 10.1042/BJ0620315
A. Anastasi, V. Erspamer, R. Exdean, Isolation and amino acid sequence of caerulein, the active decapeptide of the skin of Hyla caerulea Archives of Biochemistry and Biophysics. ,vol. 125, pp. 57- 68 ,(1968) , 10.1016/0003-9861(68)90638-3
P. D. Mayston, J. A. Barrowman, THE INFLUENCE OF CHRONIC ADMINISTRATION OF PENTAGASTRIN ON THE RAT PANCREAS Quarterly Journal of Experimental Physiology and Cognate Medical Sciences. ,vol. 56, pp. 113- 122 ,(1971) , 10.1113/EXPPHYSIOL.1971.SP002105