Cholecystokinin activation of 70-kDa S6 kinase in exocrine pancreas.
作者： Koichi Inushima , Yoshinori Okabayashi , Kazuhiko Sakaguchi , Yoko Matsumura , Sachiko Kimura
关键词: Kinase activity 、 Cholecystokinin 、 Mitogen-activated protein kinase 、 Tyrosine kinase 、 Endocrinology 、 Kinase 、 Internal medicine 、 Acinar cell 、 Biology 、 Proto-oncogene tyrosine-protein kinase Src 、 Gastrointestinal hormone
摘要: Cholecystokinin (CCK), a known mitogen for the exocrine pancreas, is shown to activate 70-kDa S6 kinase in isolated pancreatic acini. In this study, we examined kinetics and cellular mechanisms of CCK-induced p70 activation vivo vitro. Fasted mice were intraperitoneally injected with 0.01–10 μg/kg CCK analoge cerulein. Cerulein caused concentration-dependent kinase, maximal effect at 1–10 μg/kg. After 1 cerulein administration, activity was increased 5 min, peaked 10 subsequently decreased. also rapid transient Src. Prior administration tyrosine inhibitor herbimycin A compeletely inhibited cerulein-induced Src activation, while inhibition partial. Similar results obtained acinar cell line AR42J cells. These suggest that kinases, including as possible candidate, are partly implicated signaling pathway pancreas.
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