Fluorohydrocortisone and chlorohydrocortisone, highly potent derivatives of compound F.

摘要: FRIED and Sabo,1 while attempting to synthesize compound F from 11-epi-17-alpha-hydroxycorticosterone by way of a halogenated intermediate, found that the 9-alpha-chloro fluoro derivatives hydrocortisone were highly active in assay rat-liver glycogen for 11-oxygenated corticosteroids. Further studies rat Borman, Singer Numerof2 have shown these compounds potent sodium-retaining activity as well. The structural formulas are follows: present communication is concerned with metabolic therapeutic effects chlorohydrocortisone acetate fluorohydrocortisone man. Preliminary indicate whereas actions qualitatively . . .