Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene
作者： Francesca Notturno , Marta Pace , Maria V. De Angelis , Christina M. Caporale , Armando Giovannini
DOI: 10.1016/J.JNEUROIM.2008.04.003
关键词:
摘要: The SH2D2A gene encodes a T-cell-specific adapter protein involved in the negative control of T-cell activation. genotype GA13-16 homozygote promoter has been associated with susceptibility to develop multiple sclerosis. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy sharing several pathogenetic mechanisms We genotyped region 105 controls and 48 patients CIDP. found significant association between CIDP (OR 3.167; p 0.013). hypothesize that this may be implicated persistence disease.
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