The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.

摘要: The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd), was isolated from a human Chromosome (Chr) 1 cosmid library (LLNL, UK HGMP). spans 11 kilobases and contains nine exons eight introns. Four alternative transcript variants were observed in activated T cells. Three single-nucleotide polymorphisms identified within intron 2. A variable number of GA repeats found at position –340 first coding ATG. Linkage analysis using this marker CEPH families showed that is located close to D1S2624 on Chr 1q21–1q22. Physical mapping PAC BAC contig containing CD1 cluster telomeric failed identify clone harboring gene. Thus centromeric 1.