Stimulation of brain aromatic alkylamine N-methyltransferase activity by FAD and methylcobalamin
作者： Louise L. Hsu , Arnold J. Mandell
DOI: 10.1016/0024-3205(74)90077-0
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摘要: We studied the effects of methylcobalamin alone and with various reducing systems (FADH2, FAD or its analogues in combination NADH β-mercaptoethanol) on activity partially purified aromatic alkylamine N-methyltransferase (AANMT) from rat brain. As expected, specific AANMT presence was enhanced (125% control). Surprisingly, (but not FADH2 et cetera) it 175% control; int plus β-mercaptoethanol reached 307% control. Preliminary evidence suggests that induces allosteric kinetics for activated enzyme respect to methyl donor 5-methyltetrahydrofolic acid (5-MTHF).
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sci-hub.se 参考文章(13)
Shigeyuki Takeyama, Frederick T. Hatch, John M. Buchanan, Enzymatic Synthesis of the Methyl Group of Methionine: II. INVOLVEMENT OF VITAMIN B12 Journal of Biological Chemistry. ,vol. 236, pp. 1102- 1108 ,(1961) , 10.1016/S0021-9258(18)64249-8
Allan R. Larrabee, Spencer Rosenthal, Renata E. Cathou, John M. Buchanan, Enzymatic Synthesis of the Methyl Group of Methionine: IV. ISOLATION, CHARACTERIZATION, AND ROLE OF 5-METHYL TETRAHYDROFOLATE Journal of Biological Chemistry. ,vol. 238, pp. 1025- 1031 ,(1963) , 10.1016/S0021-9258(18)81253-4
Richard E. Loughlin, Howard L. Elford, John M. Buchanan, ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. VII. ISOLATION OF A COBALAMIN-CONTAINING TRANSMETHYLASE (5-METHYLTETRAHYDRO-FOLATE-HOMOCYSTEINE) FROM MAMMALIAN LIVER. Journal of Biological Chemistry. ,vol. 239, pp. 2888- 2895 ,(1964) , 10.1016/S0021-9258(18)93829-9
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
S. P. Banerjee, S. H. Snyder, Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines. Science. ,vol. 182, pp. 74- 75 ,(1973) , 10.1126/SCIENCE.182.4107.74
J. M. Saavedra, J. T. Coyle, J. Axelrod, The distribution and properties of the nonspecific N-methyltransferase in brain. Journal of Neurochemistry. ,vol. 20, pp. 743- 752 ,(1973) , 10.1111/J.1471-4159.1973.TB00035.X
K. RIDGWAY, J. B. SCOTTON, Whistling Beaches and Seabed Sand Transport Nature. ,vol. 238, pp. 212- 213 ,(1972) , 10.1038/238212A0
PIERRE LADURON, N-Methylation of Dopamine to Epinine in Brain Tissue using N-Methyltetrahydrofolic Acid as the Methyl Donor Nature. ,vol. 238, pp. 212- 213 ,(1972) , 10.1038/NEWBIO238212A0
J. R. GUEST, S. FRIEDMAN, D. D. WOODS, E. LESTER SMITH, A methyl analogue of cobamide coenzyme in relation to methionine synthesis by bacteria. Nature. ,vol. 195, pp. 340- 342 ,(1962) , 10.1038/195340A0
M. Morgan, A. J. Mandell, Indole(ethyl)amine N-methyltransferase in the brain. Science. ,vol. 165, pp. 492- 493 ,(1969) , 10.1126/SCIENCE.165.3892.492