Bilateral carcinomas of the breast with local recurrence: analysis of genetic relationship of the tumors

摘要: Local recurrence of bilateral breast carcinomas is rare, but biological interest, since it unclear as to which tumor the local related to, ipsilateral or contralateral, whether an independent neoplasm. The aim this study was investigate genetic relationship each other and their recurrences. Eight cases carcinomas, five with three without were analyzed using a microsatellite assay for 13 loci. presence loss heterozygosity instability in various tumors used clonal analysis. All eight showed divergent alterations at least two loci, ruled out relationship. Four recurrences genetically unrelated contralateral tumor. Only one that occurred 11.8 years after surgery infiltrative lobular carcinoma simultaneously distant metastases carcinoma. Although number our limited, there evidence frequently arises from