A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma.
作者： H Nakabayashi , T Hashimoto , Y Miyao , K K Tjong , J Chan
关键词:
摘要: … hepatoma cell lines, HuH-7 and huH-1/cl-2, which produce a high and a low level of AFP, respectively. We found that the low level of AFP production in huH-1/… AFP gene in hepatomas. …
osti.gov
sci-hub.se 参考文章(6)
Merilyn J. Sleigh, A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells. Analytical Biochemistry. ,vol. 156, pp. 251- 256 ,(1986) , 10.1016/0003-2697(86)90180-6
J. D. Dignam, R. M. Lebovitz, R. G. Roeder, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Research. ,vol. 11, pp. 1475- 1489 ,(1983) , 10.1093/NAR/11.5.1475
J Vacher, S. Tilghman, Dominant negative regulation of the mouse α-fetoprotein gene in adult liver. Science. ,vol. 250, pp. 1732- 1735 ,(1990) , 10.1126/SCIENCE.1702902
S. X. Cao, P. D. Gutman, H. P. Dave, A. N. Schechter, Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 5306- 5309 ,(1989) , 10.1073/PNAS.86.14.5306
G Courtois, J. Morgan, L. Campbell, G Fourel, G. Crabtree, Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters. Science. ,vol. 238, pp. 688- 692 ,(1987) , 10.1126/SCIENCE.3499668
C M Gorman, L F Moffat, B H Howard, Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Molecular and Cellular Biology. ,vol. 2, pp. 1044- 1051 ,(1982) , 10.1128/MCB.2.9.1044