A prospective, randomized, double-blind trial of intranasal dexmedetomidine and oral chloral hydrate for sedated auditory brainstem response (ABR) testing.

摘要: SummaryBackground Dexmedetomidine is increasingly used by various routes for pediatric sedation. However, there are few randomized controlled trials comparing the efficacy of dexmedetomidine to other commonly sedatives. Aim To compare sedation with intranasal oral chloral hydrate auditory brainstem response (ABR) testing. Methods In this double-blind, double-dummy study, children undergoing ABR testing were receive 3 mcg·kg−1 plus placebo (Group IN DEX) or 50 mg·kg−1 saline CH). We recorded demographic data, times from sedative administration start and completion testing, quality sedation, occurrence predefined adverse events, discharge times, return baseline activity on day testing. Results Testing rates a single dose medication higher in DEX group (89% vs 66% CH, odds ratio 95% confidence intervals 4.04 [1.3–12.6], P = 0.018). The median [95% CI)] time successful was shorter (25 [20–29] min 30 [20–49] respectively, log rank test P = 0.02) proportion whose parents reported greater than CH 64%, OR CI] 4.71 [1.34–16.6], P = 0.02). There no major events either significant differences incidence minor events. Conclusion Intranasal an effective alternative advantages dose, desired level, significantly more patients same day.