A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children
作者： V. M. Yuen , B. L. Li , D. K. Cheuk , M. K. M. Leung , T. W. C. Hui
DOI: 10.1111/ANAE.13981
关键词: Premedication 、 Dexmedetomidine 、 Saline 、 Anesthesia 、 Randomized controlled trial 、 Sedation 、 Surgery 、 Medicine 、 Placebo 、 Chloral hydrate 、 Pharmacokinetics
摘要: Chloral hydrate is commonly used to sedate children for painless procedures. Children may recover more quickly after sedation with dexmedetomidine, which has a shorter half-life. We randomly allocated 196 chloral syrup 50 mg.kg-1 and intranasal saline spray, or placebo dexmedetomidine spray 3 μg.kg-1 , 30 min before computerised tomography studies. More resisted cried drinking than syrup, 72 of 107 (67%) vs. 42 87 (48%), p = 0.009, but there was no difference 49 (46%) 40 (46%), 0.98. Sedation satisfactory in 81 (76%) 64 (74%) 0.74. Of the 173 followed up at least 4 h discharge, 38 97 (39%) had recovered normal function 32 76 (42%) 0.76. Six vomited none 0.03.
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