EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis.
作者： Anthony Genna , Aline M. Vanwynsberghe , Amélie V. Villard , Charles Pottier , Julien Ancel
关键词:
摘要: Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced ability to adapt diverse microenvironments encountered during the metastatic spread. Accordingly, EMTs play a crucial role in biology of circulating tumor cells (CTCs) and contribute their heterogeneity. Here, we review major EMT-driven properties that may help Epithelial/Mesenchymal CTCs survive bloodstream accomplish early phases colonization. We then discuss how interrogating EMT as companion biomarker could refine cancer patient management, further supporting relevance personalized medicine.
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Y Ning, W Zhang, D L Hanna, D Yang, S Okazaki, M D Berger, Y Miyamoto, M Suenaga, M Schirripa, A El-Khoueiry, H-J Lenz, Clinical relevance of EMT and stem-like gene expression in circulating tumor cells of metastatic colorectal cancer patients Pharmacogenomics Journal. ,vol. 18, pp. 29- 34 ,(2018) , 10.1038/TPJ.2016.62
Nicole Vincent Jordan, Aditya Bardia, Ben S. Wittner, Cyril Benes, Matteo Ligorio, Yu Zheng, Min Yu, Tilak K. Sundaresan, Joseph A. Licausi, Rushil Desai, Ryan M. O’Keefe, Richard Y. Ebright, Myriam Boukhali, Srinjoy Sil, Maristela L. Onozato, Anthony J. Iafrate, Ravi Kapur, Dennis Sgroi, David T. Ting, Mehmet Toner, Sridhar Ramaswamy, Wilhelm Haas, Shyamala Maheswaran, Daniel A. Haber, HER2 expression identifies dynamic functional states within circulating breast cancer cells Nature. ,vol. 537, pp. 102- 106 ,(2016) , 10.1038/NATURE19328
Alexandra Kölbl, Udo Jeschke, Ulrich Andergassen, The Significance of Epithelial-to-Mesenchymal Transition for Circulating Tumor Cells International Journal of Molecular Sciences. ,vol. 17, pp. 1308- ,(2016) , 10.3390/IJMS17081308
Zhuo Zhang, Hiroe Shiratsuchi, Nallasivam Palanisamy, Sunitha Nagrath, Nithya Ramnath, Expanded Circulating Tumor Cells from a Patient with ALK-Positive Lung Cancer Present with EML4-ALK Rearrangement Along with Resistance Mutation and Enable Drug Sensitivity Testing: A Case Study Journal of Thoracic Oncology. ,vol. 12, pp. 397- 402 ,(2017) , 10.1016/J.JTHO.2016.07.027
Archana Anantharaman, Terence Friedlander, David Lu, Rachel Krupa, Gayatri Premasekharan, Jeffrey Hough, Matthew Edwards, Rosa Paz, Karla Lindquist, Ryon Graf, Adam Jendrisak, Jessica Louw, Lyndsey Dugan, Sarah Baird, Yipeng Wang, Ryan Dittamore, Pamela L. Paris, Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients BMC Cancer. ,vol. 16, pp. 744- 744 ,(2016) , 10.1186/S12885-016-2758-3
Yu Zhang, Xiaofeng Zhang, Jinling Zhang, Bin Sun, Lulu Zheng, Jun Li, Sixiu Liu, Guodong Sui, Zhengfeng Yin, Microfluidic chip for isolation of viable circulating tumor cells of hepatocellular carcinoma for their culture and drug sensitivity assay Cancer Biology & Therapy. ,vol. 17, pp. 1177- 1187 ,(2016) , 10.1080/15384047.2016.1235665
Lianyuan Tao, Lingfu Zhang, Ying Peng, Ming Tao, Lei Li, Dianrong Xiu, Chunhui Yuan, Zhaolai Ma, Bin Jiang, Neutrophils assist the metastasis of circulating tumor cells in pancreatic ductal adenocarcinoma Medicine. ,vol. 95, pp. e4932- ,(2016) , 10.1097/MD.0000000000004932
J. Park, R. W. Wysocki, Z. Amoozgar, L. Maiorino, M. R. Fein, J. Jorns, A. F. Schott, Y. Kinugasa-Katayama, Y. Lee, N. H. Won, E. S. Nakasone, S. A. Hearn, V. Kuttner, J. Qiu, A. S. Almeida, N. Perurena, K. Kessenbrock, M. S. Goldberg, M. Egeblad, Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps Science Translational Medicine. ,vol. 8, pp. 361138- ,(2016) , 10.1126/SCITRANSLMED.AAG1711
Chun Wang, Zhaomei Mu, Inna Chervoneva, Laura Austin, Zhong Ye, Giovanna Rossi, Juan P. Palazzo, Carl Sun, Maysa Abu-Khalaf, Ronald E. Myers, Zhu Zhu, Yanna Ba, Bingshan Li, Lifang Hou, Massimo Cristofanilli, Hushan Yang, Longitudinally collected CTCs and CTC-clusters and clinical outcomes of metastatic breast cancer Breast Cancer Research and Treatment. ,vol. 161, pp. 83- 94 ,(2017) , 10.1007/S10549-016-4026-2
Yupeng Hong, Francia Fang, Qi Zhang, Circulating tumor cell clusters: What we know and what we expect (Review) International Journal of Oncology. ,vol. 49, pp. 2206- 2216 ,(2016) , 10.3892/IJO.2016.3747