Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications.
作者： Hui Wei , Jingjie Mo , Li Tao , Reb J. Russell , Adrienne A. Tymiak
DOI: 10.1016/J.DRUDIS.2013.07.019
关键词:
摘要: The higher order structure of protein therapeutics can be interrogated with hydrogen/deuterium exchange mass spectrometry (HDX-MS). HDX-MS is now a widely used tool in the structural characterization therapeutics. In this review, based workflows designed for therapeutic discovery and development processes are presented, focusing on specific applications epitope mapping protein/drug interactions biopharmaceutical comparability studies. Future trends application also described.
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Hui Wei, Adrienne A. Tymiak, Guodong Chen, Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization Springer, Boston, MA. pp. 305- 341 ,(2013) , 10.1007/978-1-4419-7862-2_8
Deepangi Pandit, Steven J. Tuske, Stephen J Coales, Sook Yen E, Anita Liu, Jessica E. Lee, Jeffrey A. Morrow, Jennifer F. Nemeth, Yoshitomo Hamuro, Mapping of discontinuous conformational epitopes by amide hydrogen/deuterium exchange mass spectrometry and computational docking Journal of Molecular Recognition. ,vol. 25, pp. 114- 124 ,(2012) , 10.1002/JMR.1169
A Abuchowski, J R McCoy, N C Palczuk, T van Es, F F Davis, Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. Journal of Biological Chemistry. ,vol. 252, pp. 3582- 3586 ,(1977) , 10.1016/S0021-9258(17)40292-4
Andrew P. Chapman, PEGylated antibodies and antibody fragments for improved therapy: a review Advanced Drug Delivery Reviews. ,vol. 54, pp. 531- 545 ,(2002) , 10.1016/S0169-409X(02)00026-1
Qian Zhang, LeAnna N. Willison, Pallavi Tripathi, Shridhar K. Sathe, Kenneth H. Roux, Mark R. Emmett, Greg T. Blakney, Hui-Min Zhang, Alan G. Marshall, Epitope mapping of a 95 kDa antigen in complex with antibody by solution-phase amide backbone hydrogen/deuterium exchange monitored by Fourier transform ion cyclotron resonance mass spectrometry. Analytical Chemistry. ,vol. 83, pp. 7129- 7136 ,(2011) , 10.1021/AC201501Z
Damian Houde, Joseph Arndt, Wayne Domeier, Steven Berkowitz, John R. Engen, Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry. Analytical Chemistry. ,vol. 81, pp. 2644- 2651 ,(2009) , 10.1021/AC802575Y
Igor A. Kaltashov, Cedric E. Bobst, Rinat R. Abzalimov, Guanbo Wang, Burcu Baykal, Shunhai Wang, Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics Biotechnology Advances. ,vol. 30, pp. 210- 222 ,(2012) , 10.1016/J.BIOTECHADV.2011.05.006
Steven A. Berkowitz, John R. Engen, Jeffrey R. Mazzeo, Graham B. Jones, Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars Nature Reviews Drug Discovery. ,vol. 11, pp. 527- 540 ,(2012) , 10.1038/NRD3746
Alain Beck, Elsa Wagner-Rousset, Daniel Ayoub, Alain Van Dorsselaer, Sarah Sanglier-Cianférani, Characterization of Therapeutic Antibodies and Related Products Analytical Chemistry. ,vol. 85, pp. 715- 736 ,(2013) , 10.1021/AC3032355
Kasper D. Rand, Martin Zehl, Ole N. Jensen, Thomas J. D. Jørgensen, Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry. Analytical Chemistry. ,vol. 81, pp. 5577- 5584 ,(2009) , 10.1021/AC9008447