Formation and function of sperm tail structures in association with sperm motility defects.

摘要: Male infertility is an increasing problem partly due to inherited genetic variations. Mutations in genes involved formation of the sperm tail cause motility defects and thus male infertility. Therefore, it crucial understand protein networks required for differentiation. Sperm produced through activation flagellum, which core structure, axoneme, resembles motile cilia. In addition this, cytoskeletal axonemal structure requires various accessory structures. These structures are important integrity long tail, capacitation, generation energy during passage fertilize oocyte. This review discusses current knowledge mechanisms their effect on fertility. The recent research based animal models variants relation function provides insights into events leading fertile production. Here we compile a view proteins development summarize factors contributing reduced motility, asthenozoospermia, underline require further research, discuss related clinical aspects human