The Bcl-2 Family

作者: Amelia Petch , Mohamed Al-Rubeai

DOI: 10.1007/1-4020-2217-4_2

关键词:

摘要: A highly regulated network of protein-protein interactions is now known to be the central underlying theme in controlling apoptosis. Understanding chemical basis these a major key understanding mechanisms this diverse pathway, while outcome offers remarkable benefits treatment many pathological diseases. It undisputed that Bcl-2 proteins regulate mitochondrial apoptotic however considerable controversy exists as how they do at molecular level. If desire apotosis various conditions or even exploit apoptosis pathway our advantage we need firstly understand precise function all pro- and anti-apoptotic proteins. vital determine which are important cell lines by pathways act carry out their before can target them. However, it clear family still for control has been shown point variety cellular damage signals multitude types.

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