Recent progress on the regulation of apoptosis by Bcl-2 family members.

摘要: Publisher Summary Programmed cell death (PCD) plays a pivotal role in the development, maintenance of homeostasis within multicellular organisms, and mutations genes known to control PCD have been associated with pathologies, such as cancer, autoimmunity, neurodegenerative disorders. A family critical regulators Bcl-2 is described along some most recent advances understanding their properties, structure, function. Although apoptosis complex process, available data suggest that members regulate focal point, where motley upstream apoptotic signals first converge, may caspase activation by preventing alterations mitochondrial would otherwise lead release proteins are capable activating downstream caspases. The formation ion channels be one mechanism which these processes. In addition multitude members, many other interesting proteins, Raf-1 can also associate and, cases, influence survival. Future studies needed test importance biochemical activities identified for family, determine relative interactions between they interact with, how protein