Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
作者： Guoping Wang , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Renxiao Wang , Guozhi Tang
DOI: 10.1021/JM060460O
关键词:
摘要: A structure-based approach was employed to design a new class of small-molecule inhibitors of Bcl-2. The most potent compound 5 (TW-37) binds to Bcl-2 with a K i value of 290 nM …
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