Oxidants and Antioxidants in Apoptosis: Role of Bcl-2

摘要: The aim of this chapter is to provide a brief overview the role reactive species and antioxidants in regulating apoptosis. mainly focuses on Bcl-2 family proteins redox regulation In some cases apoptosis, oxidation-reduction, or redox-dependent mechanisms play central role. This opens up opportunity modulate apoptosis by agents that may alter intracellular status, including antioxidants. At present, exact molecular involved remain elusive. Investigations exhibit have antiapoptotic proapoptotic properties, depending type cells apoptosis-inducing signal involved. A trend showing prevent healthy promote diseased appears be emerging. Such an observation, however, not yet supported reasonable mechanism-based details. major function regulate strategic localization protein inside cell seems necessary render its property functional.